Professor Zbigniew MADEJA, PhD

Head of the Department of Cell Biology

Room no. C120
tel. (12) 664 6142
e-mail: z.madeja@uj.edu.pl

 

Professor

1985 – Master’s degree
1991 – PhD
2003 – habilitation
2010 – Professor title
Degrees were obtained at the Jagiellonian University

Scientific Internships and Awards »

  1. Institute of Pathology, University of Bern, Switzerland.(1999)
  2. Department of Microbiology, Pathology, and Immunology, Division of Pathology, Karolinska Institute, Sweden (2001/2003)
  3. Member of the Cytobiology Committee.
  4. The Polish Academy of Sciences, Second Department (since 2003)
  5. The Polish Cell Biology Society Member of the Scientific Council of Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw (2007-2010)

Scientific Interests »

The scientific investigation concerns mechanisms of regular and carcinoma cells migration in particular:
 
the impact of homo- and heterotypical cell - to - cell contacts on the motility of carcinoma cells 
reaction of cells to topography of the base (contact guidance),
electrotaxis mechanisms (cell reaction to electrical field) and chemotaxis.
 
Additionally, studies related to stem cells biology and possible applications of synthetic cationic polyprenols for cell lipofection are carried out.

Teaching »

  • Cell biology WBt-BT165
  • Cell biology – a training for biochemists WBt-BT336
  • Workshops of cell biology WBt-BT206
  • Workshops of cell biology for biologists WBt-BT231
  • Bachelor’s degree seminar – Cell biology WBt-BT462
  • Master’s degree seminar BT - SUM – Cell Biology WBt-BT454​

Selected publicationse »

  1. Michalik M, Pierzchalska M, Włodarczyk A, Wójcik KA, Czyż J, Sanak M, Madeja Z. Transition of asthmatic bronchial fibroblasts to myofibroblasts is inhibited by cell-cell contacts. Respir Med. 2011 Oct;105(10):1467-75. Epub 2011 Jul 29. PubMed PMID: 21802932.
  2. Drukała J, Paczkowska E, Kucia M, Młyńska E, Krajewski A, Machaliński B, Madeja Z, Ratajczak MZ. Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After  Skin Burn Injury. Stem Cell Rev. 2011 May 15. [Epub ahead of print] PubMed PMID: 21573962.
  3. Drukala J, Urbanska K, Wilk A, Grabacka M, Wybieralska E, Del Valle L, Madeja  Z, Reiss K. ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro. Mol Cancer. 2010 Jun 22;9:159. PubMed PMID: 20569465; PubMed Central PMCID:PMC2912247.
  4. Sroka J, Antosik A, Czyz J, Nalvarte I, Olsson JM, Spyrou G, Madeja Z. Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells. Biol Cell. 2007 Jun 21.
  5. Madeja Z, Sroka J, Nystrom C, Bjorkhem-Bergman L, Nordman T, Damdimopoulos A, Nalvarte I, Eriksson LC, Spyrou G, Olsson JM, Bjornstedt M. The role of thioredoxin reductase activity in selenium-induced cytotoxicity. Biochem Pharmacol. 69: 1765-72, 2005.
  6. Miekus K, Czernik M, Sroka J, Czyz J, Madeja Z. Contact stimulation of prostate cancer cell migration: the role of gap junctional coupling and migration stimulated by heterotypic cell-to-cell contacts in determination of the metastatic phenotype of Dunning rat prostate cancer cells. Biol Cell. 97, 893-903, 2005.
  7. Czyz J, Madeja Z, Irmer U, Korohoda W, Hulser DF. Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. Int J Cancer. 114, 12-18, 2005.
  8. Djamgoz MBA, Mycielska M, Madeja Z, Fraser SP, and Korohoda W. Directional movement of rat prostate cancer cells in electric field: Control by voltage-gated Na+ channel activity. J Cell Sci 114: 2697-2705, 2001.
  9. Szymkiewicz I, Madeja Z, Żaczek A, Sroka J, Miękus K, and Korohoda W. Contact-activated migration of melanoma B16 and sarcoma XC cells. Biochem Cell Biol, 79: 425-440. 2001.
  10. Korohoda W and Madeja Z. Contact of sarcoma cells with aligned fibroblasts accelerates their displacement:computer-assisted analysis of tumour cell locomotion in co-culture. Biochem Cell Biol, 75: 263-276, 1997.
  11. Korohoda W, Golda J, Sroka J, Wojnarowicz A, Jochym P and Madeja Z. Chemotaxis of Amoeba proteus in the developing pH gradient within a pocketlike chamber studied with the computer assisted method. Cell Motil. Cytoskel. 38, 38-53, 1997.