Professor Zbigniew MADEJA, PhD
Head of the Department of Cell Biology
Room no. C120
tel. (12) 664 6142
e-mail: z.madeja@uj.edu.pl
Professor
1985 – Master’s degree
1991 – PhD
2003 – habilitation
2010 – Professor title
Degrees were obtained at the Jagiellonian University
Scientific Internships and Awards »
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Institute of Pathology, University of Bern, Switzerland.(1999)
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Department of Microbiology, Pathology, and Immunology, Division of Pathology, Karolinska Institute, Sweden (2001/2003)
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Member of the Cytobiology Committee.
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The Polish Academy of Sciences, Second Department (since 2003)
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The Polish Cell Biology Society Member of the Scientific Council of Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw (2007-2010)
Scientific Interests »
The scientific investigation concerns mechanisms of regular and carcinoma cells migration in particular:
• the impact of homo- and heterotypical cell - to - cell contacts on the motility of carcinoma cells
• reaction of cells to topography of the base (contact guidance),
• electrotaxis mechanisms (cell reaction to electrical field) and chemotaxis.
Additionally, studies related to stem cells biology and possible applications of synthetic cationic polyprenols for cell lipofection are carried out.
Teaching »
- Cell biology WBt-BT165
- Cell biology – a training for biochemists WBt-BT336
- Workshops of cell biology WBt-BT206
- Workshops of cell biology for biologists WBt-BT231
- Bachelor’s degree seminar – Cell biology WBt-BT462
- Master’s degree seminar BT - SUM – Cell Biology WBt-BT454
Selected publicationse »
- Michalik M, Pierzchalska M, Włodarczyk A, Wójcik KA, Czyż J, Sanak M, Madeja Z. Transition of asthmatic bronchial fibroblasts to myofibroblasts is inhibited by cell-cell contacts. Respir Med. 2011 Oct;105(10):1467-75. Epub 2011 Jul 29. PubMed PMID: 21802932.
- Drukała J, Paczkowska E, Kucia M, Młyńska E, Krajewski A, Machaliński B, Madeja Z, Ratajczak MZ. Stem Cells, Including a Population of Very Small Embryonic-Like Stem Cells, are Mobilized Into Peripheral Blood in Patients After Skin Burn Injury. Stem Cell Rev. 2011 May 15. [Epub ahead of print] PubMed PMID: 21573962.
- Drukala J, Urbanska K, Wilk A, Grabacka M, Wybieralska E, Del Valle L, Madeja Z, Reiss K. ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro. Mol Cancer. 2010 Jun 22;9:159. PubMed PMID: 20569465; PubMed Central PMCID:PMC2912247.
- Sroka J, Antosik A, Czyz J, Nalvarte I, Olsson JM, Spyrou G, Madeja Z. Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells. Biol Cell. 2007 Jun 21.
- Madeja Z, Sroka J, Nystrom C, Bjorkhem-Bergman L, Nordman T, Damdimopoulos A, Nalvarte I, Eriksson LC, Spyrou G, Olsson JM, Bjornstedt M. The role of thioredoxin reductase activity in selenium-induced cytotoxicity. Biochem Pharmacol. 69: 1765-72, 2005.
- Miekus K, Czernik M, Sroka J, Czyz J, Madeja Z. Contact stimulation of prostate cancer cell migration: the role of gap junctional coupling and migration stimulated by heterotypic cell-to-cell contacts in determination of the metastatic phenotype of Dunning rat prostate cancer cells. Biol Cell. 97, 893-903, 2005.
- Czyz J, Madeja Z, Irmer U, Korohoda W, Hulser DF. Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. Int J Cancer. 114, 12-18, 2005.
- Djamgoz MBA, Mycielska M, Madeja Z, Fraser SP, and Korohoda W. Directional movement of rat prostate cancer cells in electric field: Control by voltage-gated Na+ channel activity. J Cell Sci 114: 2697-2705, 2001.
- Szymkiewicz I, Madeja Z, Żaczek A, Sroka J, Miękus K, and Korohoda W. Contact-activated migration of melanoma B16 and sarcoma XC cells. Biochem Cell Biol, 79: 425-440. 2001.
- Korohoda W and Madeja Z. Contact of sarcoma cells with aligned fibroblasts accelerates their displacement:computer-assisted analysis of tumour cell locomotion in co-culture. Biochem Cell Biol, 75: 263-276, 1997.
- Korohoda W, Golda J, Sroka J, Wojnarowicz A, Jochym P and Madeja Z. Chemotaxis of Amoeba proteus in the developing pH gradient within a pocketlike chamber studied with the computer assisted method. Cell Motil. Cytoskel. 38, 38-53, 1997.