Paweł FERDEK, PhD

Room no. C145 (2.0.33)
Tel. no. +48 12 664 6218
e-mail: pawel.ferdek@uj.edu.pl

 

2007 – Master of Science in Biotechnology, specialisation: Medical Biotechnology, Jagiellonian University, Krakow, Poland
2008 – Master of Research in Biomedical Sciences, University of Liverpool, Liverpool, United Kingdom
2012 – Doctor of Philosophy in Bioscience, Cardiff University, Cardiff, United Kingdom

Scientific Internships and Awards »

  1. Aug 2012 – Jan 2018 – Postdoctoral Research Associate, The Medical Research Council Group, School of Biosciences, Cardiff University, Cardiff, United Kingdom
  2. Aug/Sept 2016 – Visiting Scholar, School of Live Sciences, Xiamen University, Xiamen, China
  3. Jan 2012 – Mar 2012 – Research Associate, The Medical Research Council Group, School of Biosciences, Cardiff University, Cardiff, United Kingdom
  4. Oct 2008 – Dec 2011 – PhD Student, (1) The Physiological Laboratory, University of Liverpool, Liverpool, United Kingdom, (2) School of Biosciences, Cardiff University, Cardiff, United Kingdom
  5. Oct 2007 – Jun 2008 – Three 3-month internships as an MRes Student, Department of Cellular and Molecular Physiology / Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
  6. Jun 2006 – Jun 2007 – Visiting Graduate Student, 1-year internship, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia, USA

Scientific Interests »

  • Calcium signalling in physiology and pathophysiology of the pancreas
  • Biology of pancreatic stellate cells and mechanisms that underlie pancreatic fibrosis
  • Bcl-2 family proteins

Selected publications »

  1. Ferdek PE*, Jakubowska MA*. Biology of pancreatic stellate cells - more than just pancreatic cancer. Pflugers Arch - Eur J Physiol. 2017, 469(9): 1039-1050.
  2. Ferdek PE, Jakubowska MA, Nicolaou P, Gerasimenko JV, Gerasimenko OV, Petersen OH. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death Dis 2017, 8(3): e2640.
  3. Ferdek PE, Jakubowska MA, Gerasimenko JV, Gerasimenko OV, Petersen OH. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. J Physiol 2016, 594(21): 6147-6164.
  4. Jakubowska MA, Ferdek PE, Gerasimenko OV, Gerasimenko JV, Petersen OH. Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol 2016, 6(8): 160149.
  5. Gerasimenko JV*, Gryshchenko O*, Ferdek PE*, Stapleton E, Hebert TO, Bychkova S, Peng S, Begg M, Gerasimenko OV, Petersen OH. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proc Natl Acad Sci U S A 2013, 110(32): 13186-13191.
  6. Ferdek PE, Gerasimenko JV, Peng S, Tepikin AV, Petersen OH, Gerasimenko OV. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr Biol 2012, 22(13): 1241-1246.
  7. Gerasimenko JV, Lur G, Ferdek P, Sherwood MW, Ebisui E, Tepikin AV, Mikoshiba K, Petersen OH, Gerasimenko OV. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proc Natl Acad Sci U S A 2011, 108(14): 5873-5878.
  8. Gerasimenko J*, Ferdek P*, Fischer L, Gukovskaya AS, Pandol SJ. Inhibitors of Bcl-2 protein family deplete ER Ca2+ stores in pancreatic acinar cells. Pflugers Arch 2010, 460(5): 891-900.
  9. Baumgartner HK, Gerasimenko JV, Thorne C, Ferdek P, Pozzan T, Tepikin AV, Petersen OH, Sutton R, Watson AJ, Gerasimenko OV. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem 2009, 284(31): 20796-20803.
  10. Johnson JR, Ferdek P, Lian LY, Barclay JW, Burgoyne RD, Morgan A. Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans. Biochem J 2009, 418(1): 73-80.
  11. Hughes JE, Srinivasan S, Lynch KR, Proia RL, Ferdek P, Hedrick CC. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circ Res 2008, 102(8): 950-958.