Professor Jarosław CZYŻ, PhD,

 

room no. C23
tel. no. (12) 664 6146
e-mail: jarek.czyz@uj.edu.pl

 

assistant professor

1991- MSc
1996- PhD
2008 – habilitation
2015- Professor degree

Degrees awarded by the Jagiellonian University

Scientific Internships and Awards »

  1. Post-doctoral internship in the Department of Biophysics of the Institute of Biology of the University in Stuttgart, Germany (1998);
  2. Study visit in the Department of Biophysics of the Institute of Biology of the Stuttgart University (Germany) as a part the scholarship funded by NATO/DAAD (3 months, 1999);
  3. Study visit in the In vitro Differentiation Laboratory of the Institute of Plant Genetics in Gatersleben (IPK, Germany) as a part of the scholarship funded by DFG (3 months, 2000);
  4. Post-doctoral internship in the In vitro Differentiation Laboratory of the Institute of Plant Genetics in Gatesleben, IPK, Germany (2000-2002);
  5. Study visit in the In vitro Differentiation Laboratory of the Institute of Plant Genetics in Gatesleben, IPK, Germany (1 month, 2004)

Scientific Interests »

  • The role of connexins and gap junctional couplings in the carcinoma progression and metastasis
  • Identification of signal transduction that determines heterogeneity of carcinoma cells population – carcinoma stem cells
  • Signal transduction between regular and carcinoma cells within the “metastatic niche”
  • Mechanisms of the impact of substances included in plant extracts based on properties of carcinoma cells that are decisive for metastasis

Teaching »

Intercellular communication – WBt-324

Selected Publications »

  1. Czyz J, Madeja Z, Irmer U, Korohoda W, Hulser DF. Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. Int J Cancer. (2005), 114:12-18.
  2. Nikolowa T, Czyż J, Rolletschek A, Błyszczuk P, Fuchs J, Jovtchev G, Schuderer J, Kuster N, Wobus AM. Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells. FASEB J. (2005), 19:1685-1688.
  3. Miekus K, Czernik M, Sroka J, Czyż J, Madeja Z. Contact stimulation of prostate cancer cell migration: The role of gap junctional coupling and migration stimulated by heterotypic cell-to-cell contacts in determination of metastatic phenotype of Dunning rat prostate cancer cells. Biol. Cell (2005), 97: 893-903.
  4. Wiese C, Rolletschek A, Kania G, Navarrete-Santos A, Anisimov SV, Steinfarz B, Tarasov KV, Brugh SA, Zahanich I, Ruschenschmidt C, Beck H, Błyszczuk P, Czyż J, Heubach JF, Ravens U, Horstmann O, St-Onge L, Braun T, Brustle O, Boheler KR, Wobus AM. Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro. Stem Cells. (2006), 24(9): 2085-97.
  5. Czyz J. The stage-specific function of gap junctions during tumourigenesis. Cell Mol Biol Lett. (2008), 13(1):92-102.
  6. Daniel-Wójcik A, Misztal K., Bechyne I, Sroka J, Miękus K, Madeja Z Czyz J. Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations Int J Oncol (2008), 33: 309-315.
  7. Sroka J, Czyz J, Wojewoda M, Madeja Z. The inhibitory effect of diphenyltin on gap junctional intercellular communication in HEK-293 cells is reduced by thioredoxin reductase 1.Toxicol Lett. (2008),183:45-51.
  8. Baran B, Bechyne I, Siedlar M, Szpak K, Mytar B, Sroka J, Laczna E, Madeja Z, Zembala M, Czyz J. Blood monocytes stimulate migration of human pancreatic carcinoma cells in vitro: the role of tumour necrosis factor - alpha. Eur J Cell Biol. 2009 Dec;88(12):743-52.
  9. Wybieralska E, Szpak K,  Górecki P, Bonarek P, Miękus K, Drukała J, Majka M, Reiss K, Madeja Z,  Czyż J. Fenofibrate attenuates contact-stimulated cell motility and gap junctional coupling in DU-145 human prostate cancer cell population.  Oncology Rep. 26(2):447-53.
  10. Michalik M, Pierzchalska M, Włodarczyk A, Wójcik KA, Czyż J, Sanak M, Madeja Z.Transition of asthmatic bronchial fibroblasts to myofibroblasts is inhibited by cell-cell contacts. Respir Med. 2011 Oct;105(10):1467-75.
  11. Bechyne I, Szpak K, Madeja Z, Czyz J. Functional heterogeneity of non-small lung adenocarcinoma cell sub-populations. Cell Biol Int. 2011 doi:10.1042/CBI20110151